Savage Mind to Savage Machine: Techniques and Disciplines of Creativity, c. 1880-1985

This dissertation explores how the imagined semiotic mode of the unconscious, illiterate "savage" was instrumental to twentieth-century technologies of production in two respects: firstly, in the context of a global division of labor, as a way to disqualify certain groups' intellectual products from the category of intellectual property; and, secondly, in disciplines of aesthetic production, as an imaginary model on which to base new technologies of design and communication. In my dissertation, Savage Mind to Savage Machine: Techniques and Disciplines of Creativity (1870-1985), I argue that class inequalities under capitalism have been linked to the ongoing formulation of two distinct--albeit tacit--categories of epistemic subjectivity: one whose creative intellectual processes are believed to constitute personal property, and one whose creative intellectual processes--because these are deemed rote or unconscious--are not regarded as the property of those who wield them. This epistemic apartheid exists despite the fact that the unconscious psyche or, as I call it, the "Savage Mind," was, at the same time, repeatedly invoked by modernist designers in their efforts to formulate creative technologies, ones that tended increasingly towards digital modes of production. The history I examine in the dissertation reveals how modernist design has implicitly constituted itself as the process through which unconscious, magical creativity becomes consciously systematized and reified as technological, scientific forms of production. The dissertation is structured around four disciplinary paradigms of design, which collectively span the late nineteenth to late twentieth centuries--industrial design, architecture, environmental design, and media arts--and asks how and why each of these sub-disciplines invoked "savage thought" to develop new methods of creativity. While it is well-known that Europe's avant-gardes often imitated the visual forms of so-called primitive societies, there is scant scholarship accounting for how the alleged thought processes of an "originary" intelligence--gleaned from the theories of anthropologists, psychologists, and other social scientists--were translated into modernist design methods. Designers in fact hoped to discover in "primitive" and magical thought specific intellectual mechanisms for linking designed things to larger contexts of signification, a search that dovetailed with early endeavors in the field of Artificial Intelligence to devise computational languages and environments. The Savage Mind thus lies at the heart of new media technologies, even while intellectual property in those technologies remains the purview of a scientific elite

Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics: protocol for a prospective matched cohort study in transgender individuals (the GAME study)

INTRODUCTION: Gender affirming hormone therapy (GAHT) is increasingly used by transgender individuals and leads to shifts in sex hormone levels. Skeletal muscle is highly responsive to hormone activity, with limited data on the effects of GAHT on different human tissues. Here, we present the protocol for the GAME study (the effects of Gender Affirming hormone therapy on skeletal Muscle training and Epigenetics), which aims to uncover the effects of GAHT on skeletal muscle 'omic' profiles (methylomics, transcriptomics, proteomics, metabolomics) and markers of skeletal muscle health and fitness. METHODS AND ANALYSIS: This study is a prospective age-matched cohort study in transgender adults commencing GAHT (n=80) and age-matched individuals not commencing GAHT (n=80), conducted at Austin Health and Victoria University in Victoria, Australia. Assessments will take place prior to beginning GAHT and 6 and 12 months into therapies in adults commencing GAHT. Age-matched individuals will be assessed at the same time points. Assessments will be divided over three examination days, involving (1) aerobic fitness tests, (2) muscle strength assessments and (3) collection of blood and muscle samples, as well as body composition measurements. Standardised diets, fitness watches and questionnaires will be used to control for key confounders in analyses. Primary outcomes are changes in aerobic fitness and muscle strength, as well as changes in skeletal muscle DNA methylation and gene expression profiles. Secondary outcomes include changes in skeletal muscle characteristics, proteomics, body composition and blood markers. Linear mixed models will be used to assess changes in outcomes, while accounting for repeated measures within participants and adjusting for known confounders. ETHICS AND DISSEMINATION: The Austin Health Human Research Ethics Committee (HREC) and Victoria University HREC granted approval for this study (HREC/77146/Austin-2021). Findings from this project will be published in open-access, peer-reviewed journals and presented to scientific and public audiences. TRIAL REGISTRATION NUMBER: ACTRN12621001415897; Pre-results

Architecture and the Environment:Field Notes

These Field Notes, on the topic of Architecture and the Environment, elucidate how problems raised in the environmental humanities have informed architectural history, and in turn, what architectural history has to contribute to this emerging field. The short essays explore specific \u27positions\u27 in the overarching debate, identifying a radical return to critical theory and the embrace of the fundamentally transdisciplinary nature of environmental humanities and architectural history. While the positions advocate for a serious investigation of architects\u27 texts and ideas on environmental issues, the collection also champions a broader engagement with Anthropocene questions and proposes to adopt the environment as an intellectual perspective from which to look upon the world

GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida

The plasma membranes of the divergent eukaryotic parasites, Leishmania and Trypanosoma, are highly specialised, with a thick coat of glycoconjugates and glycoproteins playing a central role in virulence. Unusually, the majority of these surface macro-molecules are attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. In mammalian cells and yeast, many GPI-anchored molecules associate with sphingolipid and cholesterol-rich detergent-resistant membranes, known as lipid rafts. Here we show that GPI-anchored parasite macro-molecules (but not the dual acylated Leishmania surface protein (hydrophilic acylated surface protein) or a subset of the GPI-anchored glycoinositol phospholipid glycolipids) are enriched in a sphingolipid/sterol-rich fraction resistant to cold detergent extraction. This observation is consistent with the presence of functional lipid rafts in these ancient, highly polarised organisms